In 1494 Charles VIII of France marching against Rome stopped at Bracciano, and in 1496 the city was besieged by a papal army led by Giovanni di Candia, son of Pope Alexander VI Borgia, but was able to resist the siege. Also Cesare Borgia, another of Alexander's natural sons, was unsuccessful in his siege of the castle some years later. In 1558 Paolo Giordano I Orsini married Isabella de' Medici, daughter of Cosimo I, Grandduke of Tuscany, and was granted the title of duke of Bracciano.
In the early 17th century Paolo Giordano II ordered the construction of an aqueduct from the Manziana hills to the lake, which led to the establishment of a papermill and printing press, which promoted an early industrial development in the area, with the mining of sulphur and iron and the production of tapestries. In 1696 the castle was auctioned and passed to Livio Odescalchi. Then in 1804 the Odescalchi sold it to the Torlonia family, but in 1861 when prince Livio III Odescalchi married a Polish heiress, Sofia Branicka, and was able to redeem the property of the castle, which still belongs to his descendants.